Project information

Inhibition of deregulated NO synthase as a potential treatment for DMD pathology (NOS inhibiton for DMD treatment)

Project Identification
MUNI/IGA/1367/2021
Project Period
1/2022 - 12/2022
Investor / Pogramme / Project type
Masaryk University
MU Faculty or unit
Faculty of Medicine

Nitric oxide synthase (NOS) is deregulated in Duchenne muscular dystrophy (DMD) pluripotent stem cells leading to higher levels of reactive oxygen species, mutagenesis and DNA damage which can be attenuated by NOS inhibition. Cardiac differentiation is also impaired in DMD but can improved by NOS inhibition as pilot data show. This project aims to characterize the scope and mechanism of action of the observed attenuation of negative effects of NOS deregulation in cardiac development in DMD.

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