Informace o projektu

Inhibition of deregulated NO synthase as a potential treatment for DMD pathology (NOS inhibiton for DMD treatment)

Kód projektu
MUNI/IGA/1367/2021
Období řešení
1/2022 - 12/2022
Investor / Programový rámec / typ projektu
Masarykova univerzita
Fakulta / Pracoviště MU
Lékařská fakulta

Nitric oxide synthase (NOS) is deregulated in Duchenne muscular dystrophy (DMD) pluripotent stem cells leading to higher levels of reactive oxygen species, mutagenesis and DNA damage which can be attenuated by NOS inhibition. Cardiac differentiation is also impaired in DMD but can improved by NOS inhibition as pilot data show. This project aims to characterize the scope and mechanism of action of the observed attenuation of negative effects of NOS deregulation in cardiac development in DMD.

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