Project information

Project information
The relationship between retinal nerve fiber thickness and retinal functional sensitivity during OCT and static perimeter examinations (REFITSEN)

Project Identification
Project Period
1/2024 - 12/2024
Investor / Pogramme / Project type
Masaryk University
MU Faculty or unit
Faculty of Medicine
Project Website
OCT, perimeter, MD, papila, macula, retina

In our study, we will use two sophisticated clinical devices that are suitable for measuring both structural and functional changes in the retina of the eye, not only in patients with disease, but also in healthy patients, where these changes can occur, for example, as a result of aging.
The OCT Zeiss Stratus is a device that, thanks to its high resolution, allows to create tomographic images in the examined tissues of the eye. It works on the principle of light reflection. Tissues can be imaged in the range of 1-15 micrometers, i.e. better than when using conventional ultrasound methods (Šeda J., 2013). A tomographic image is composed of individual A scans. In this, linear way, we gradually create a B scan. B scans allow you to create a 3D view. An important parameter of this device is the measurement of RNFL thickness. The device creates a circular B scan with a diameter of 3.4 mm around the optical disc. After scanning the image, a quantitative and graphic analysis is performed. The scan is so-called straightened and the RNFL boundaries are found. In the retina, it is the first layer below the vitreous, which fills the entire eyeball. The measured RNFL thickness is then compared to a database of individuals of similar age, sex, and race. This analysis is one of the most important that this device offers.


In our study, we did not demonstrate a statistically significant relationship between the average thickness of the retinal nerve fiber layer (RNFL) and the average value of retinal functional sensitivity (r = 0.18, p = 0.34) in the right eyes as well as in the left eyes of the examined subjects (r = 0.20, p = 0.29). We also did not find a statistically significant relationship secondarily between the variable called the spherical equivalent of the refractive error (SE) and the average thickness of the retina in the macula in the right eyes (r = 0.34, p = 0.06) and left eyes (r = 0.18, p = 0.32).

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Sustainable Development Goal No.  3 – Good health and well-being Sustainable Development Goal No.  4 – Quality education Sustainable Development Goal No.  8 – Decent work and economic growth Sustainable Development Goal No.  9 – Industry, innovation and infrastructure Sustainable Development Goal No.  17 – Partnerships for the goals


Total number of publications: 1

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