Publication details

Specific conditions of tumor microenvironment enhance cytotoxicity of disulfiram, tetrathiomolybdate and wedelolactone to breast cancer and neuroblastoma cells

Authors

BENEŠ Petr NAVRÁTILOVÁ Jarmila HANKEOVÁ Tereza NEHYBOVÁ Tereza KNOPFOVÁ Lucia ŠMARDA Jan

Year of publication 2013
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description Our study was designed to analyze the effects of hypoxia, acidosis, and limited glucose supply to cytotoxicity of disulfiram, tetrathiomolybdate and wedelolactone to breast cancer and neuroblastoma cells. We found that cytotoxicity of these drugs can be strongly enhanced by manipulating tissue culture conditions that simulate the character of tumor microenvironment.
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