Publication details

A Soluble Fucose-Specific Lectin from Aspergillus fumigatus Conidia - Structure, Specificity and Possible Role in Fungal Pathogenicity

Authors

HOUSER Josef KOMÁREK Jan KOSTLÁNOVÁ Nikola CIOCI Gianluca VARROT Annabelle KERR Sheena LAHMANN Martina BALLOY Viviane FAHY John CHIGNARD Michel IMBERTY Anne WIMMEROVÁ Michaela

Year of publication 2013
Type Article in Periodical
Magazine / Source PLOS ONE
MU Faculty or unit

Central European Institute of Technology

Citation
Web Original article web page - full text free.
Doi http://dx.doi.org/10.1371/journal.pone.0083077
Field Biochemistry
Keywords lectin; Aspergillus fumigatus; protein structure
Description We focused on the lectin AFL, which was prepared in recombinant form and characterized. Its binding properties were studied using hemagglutination and glycan array analysis. We determined the specificity of the lectin towards L-fucose and fucosylated oligosaccharides. AFL was crystallized and its structure was solved. The combination of affinity to human epithelial epitopes, production by conidia and pro-inflammatory activity shows that AFL might be an important virulence factor
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