Is collagen matrix suitable as a carrier in periodontal regeneration?
|Year of publication||2015|
|MU Faculty or unit|
|Description||• Aim The aim of the present study was to investigate the capacity of collagen matrix (CM) as a carrier for different blood derivates to improve the periodontal regeneration. • Material and Methods In the study 28 white New Zealand rabbits were used after approval from the ethical committee. After administration of premedication and general anesthesia, we created circular artificial defects on the buccal mucosa. The CM (Mucograft, Geistlich Pharma AG, Switzerland) was implanted into the defect alone (positive control), together with Platelet-Rich Plasma (CM+PRP), with Platelet-Rich Fibrin (CM+PRF), or was left untreated (negative control). • Results The samples were analyzed at days 1, 7, and 28. Histological, immunohistochemical and molecular analysis were conducted and the capacity of CM as a carrier was evaluated. Light microscope revealed marginal differences among groups in wound reepitelization, neoangiogenesis, granulation tissue and collagen formation, but no differences in the markers of acute or chronic inflammation (Kruskal-Wallis, p?0.05). • Conclusion The advantages and disadvantages of CM as a carrier for blood derivates will be discussed. Our findings have not confirmed yet that CM as a carrier for the tested substances would improve wound healing and the outcomes of periodontal surgery therapy. The study was supported by the grant IGA NT14321 and by project MUNI/A/0951/2013.|