Publication details

Haplotype analysis of interleukin-6 gene promoter polymorphisms in patients with chronic periodontitis and diabetes mellitus

Authors

VALOVÁ Simona BOŘILOVÁ LINHARTOVÁ Petra KAŇKOVÁ Kateřina POSKEROVÁ Hana VOKURKA Jan FASSMANN Antonín IZAKOVIČOVÁ HOLLÁ Lydie

Year of publication 2015
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description The aim of our study was to investigate the association of single nucleotide polymorphisms at positions -174G/C (rs1800795), -572G/C (rs1800796) and -597G/A (rs1800797), and their combinations (haplotypes) in patients with CP, type 1 DM (T1DM) and type 2 DM (T2DM) in comparison with healthy controls. Our results indicate that different IL-6 promoter haplotypes can affect the risk for CP and DM development. However, the individual IL-6 gene promoter polymorphisms do not act independently and may affect each other.
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