Haplotype analysis of interleukin-6 gene promoter polymorphisms in patients with chronic periodontitis and diabetes mellitus

• Authors: VALOVÁ Simona; BOŘILOVÁ LINHARTOVÁ Petra; KAŇKOVÁ Kateřina; POSKEROVÁ Hana; VOKURKA Jan; FASSMANN Antonín; IZAKOVIČOVÁ HOLLÁ Lydie
• Year of publication: 2015
• Type: Conference abstract
• MU Faculty or unit: Faculty of Medicine
• Description: The aim of our study was to investigate the association of single nucleotide polymorphisms at positions -174G/C (rs1800795), -572G/C (rs1800796) and -597G/A (rs1800797), and their combinations (haplotypes) in patients with CP, type 1 DM (T1DM) and type 2 DM (T2DM) in comparison with healthy controls. Our results indicate that different IL-6 promoter haplotypes can affect the risk for CP and DM development. However, the individual IL-6 gene promoter polymorphisms do not act independently and may affect each other.

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