Publication details

Leptin and Ventilation in Heart Failure Response


ČUNDRLE Ivan PRACHI Singh JOHNSON Bruce D. SCOTT Christopher G. OLSON Lyle J.

Year of publication 2015
Type Article in Periodical
Magazine / Source Chest
MU Faculty or unit

Faculty of Medicine

Field Cardiovascular diseases incl. cardiosurgery
Keywords Leptin; Heart Failure
Description We appreciate the comments of Drs Javaheri and Schwartz about our article in CHEST . 1 Our study was observational, and, as such, we cannot comment on causality regarding leptin and ventilatory drive. Furthermore, caution seems indicated when extrapolating fi ndings from ob/ob mice to human heart failure (HF). First, ob/ob mice are primarily a model of obesity, whereas chronic HF is frequently associated with cachexia. Second, leptin has been shown to infl uence lung development, 2 which may aff ect ob/ob mice but not patients with HF who experience leptin defi ciency only in adulthood. Third, in knock-out animal models, com pensatory mechanisms may alter normal physiologic controls and thereby not produce the expected effects of gene deletion.

You are running an old browser version. We recommend updating your browser to its latest version.

More info