Informace o publikaci

Leptin and Ventilation in Heart Failure Response

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ČUNDRLE Ivan PRACHI Singh JOHNSON Bruce D. SCOTT Christopher G. OLSON Lyle J.

Rok publikování 2015
Druh Článek v odborném periodiku
Časopis / Zdroj Chest
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1378/chest.15-0326
Obor Kardiovaskulární nemoci včetně kardiochirurgie
Klíčová slova Leptin; Heart Failure
Popis We appreciate the comments of Drs Javaheri and Schwartz about our article in CHEST . 1 Our study was observational, and, as such, we cannot comment on causality regarding leptin and ventilatory drive. Furthermore, caution seems indicated when extrapolating fi ndings from ob/ob mice to human heart failure (HF). First, ob/ob mice are primarily a model of obesity, whereas chronic HF is frequently associated with cachexia. Second, leptin has been shown to infl uence lung development, 2 which may aff ect ob/ob mice but not patients with HF who experience leptin defi ciency only in adulthood. Third, in knock-out animal models, com pensatory mechanisms may alter normal physiologic controls and thereby not produce the expected effects of gene deletion.

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