Publication details

The role of the endoplasmic reticulum stress in stemness, pluripotency and development

Authors

KRATOCHVÍLOVÁ Kateřina MORÁŇ Lukáš PAĎOUROVÁ Stanislava STEJSKAL Stanislav TESAŘOVÁ Lenka ŠIMARA Pavel HAMPL Aleš KRONTORÁD KOUTNÁ Irena VAŇHARA Petr

Year of publication 2016
Type Article in Periodical
Magazine / Source European Journal of Cell Biology
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1016/j.ejcb.2016.02.002
Field Morphological specializations and cytology
Keywords Endoplasmic reticulum stress; Unfolded protein response; Embryonic stem cells; Pluripotency; Development
Description The molecular machinery of endoplasmic reticulum (ER) integrates various intracellular and extracellular cues to maintain homeostasis in diverse physiological or pathological scenarios. ER stress and the unfolded protein response (UPR) have been found to mediate molecular and biochemical mechanisms that affect cell proliferation, differentiation, and apoptosis. Although a number of reviews on the ER stress response have been published, comprehensive reviews that broadly summarize ER physiology in the context of pluripotency, embryonic development, and tissue homeostasis are lacking. This review complements the current ER literature and provides a summary of the important findings on the role of the ER stress and UPR in embryonic development and pluripotent stem cells.
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