Publication details

Sinusová histiocytóza s masivní lymfadenopatií: FDG-PET/CT dokumentovaná parciální remise po léčbě 2-chlorodeoxyadenozinem

Title in English Sinus histiocytosis with massive lymphadenopathy: FDC-PET/CT documented partial remission after treatment with 2-chlorodeoxyadenosine
Authors

ADAM Zdeněk MAŠLAŇ Jiří KŘEN Leoš KODET Roman KOUKALOVÁ Renata ŘEHÁK Zdeněk ČERVINEK Libor POUR Luděk KREJČÍ Marta SANDECKÁ Viera KRÁL Zdeněk MAYER Jiří

Year of publication 2016
Type Article in Periodical
Magazine / Source Vnitřní lékařství
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords Castleman's disease; lenalidomide; Rosai-Dorfman disease; rituximab; sinus lymphadenopathy with massive lymphadenopathy; thalidomide; 2-chlorodeoxyadenosine
Description Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) is a very rare disease belonging to a group of histiocytoses (more precisely non-Langerhans cell histiocytoses). Rosai-Dorfman disease is characterised by the presence of atypical histiocytic cells in the sinuses of lymph nodes or in the extranodal lymphoid tissue, absorbing lymphocytes and plasma cells. The structure and function of the absorbed cells is not impaired and they can leave histiocytes as viable cells. This effect is called emperipolesis, whereas ingestion of cells with their destruction is called phagocytosis. In our text we describe a patient with this disease located, characteristically, in supracla-vicular lymph nodes, but also in mediastinal lymph nodes. Along with lymphadenopathy skin alterations appeared which were both clinically and histologically described as eczema dermatitis. At the same time as lymphadenopathy also strong headaches started which the patient had never suffered before.
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