Publication details

Young inversion with multiple linked QTLs under selection in a hybrid zone

Authors

LEE Cheng-Ruei WANG Baosheng MOJICA Julius P. MANDÁKOVÁ Terezie PRASAD Kasavajhala V. S. K. GOICOECHEA Jose Luis PERERA Nadeesha HELLSTEN Uffe HUNDLEY Hope N. JOHNSON Jenifer GRIMWOOD Jane BARRY Kerrie FAIRCLOUGH Stephen JENKINS Jerry W. YU Yeisoo KUDRNA Dave ZHANG Jianwei TALAG Jayson GOLSER Wolfgang GHATTAS Kathryn SCHRANZ M. Eric WING Rod LYSÁK Martin SCHMUTZ Jeremy ROKHSAR Daniel S. MITCHELL-OLDS Thomas

Year of publication 2017
Type Article in Periodical
Magazine / Source Nature Ecology and Evolution
MU Faculty or unit

Central European Institute of Technology

Citation
Web https://www.nature.com/articles/s41559-017-0119
Doi http://dx.doi.org/10.1038/s41559-017-0119
Field Genetics and molecular biology
Keywords QUANTITATIVE TRAIT LOCI; GENERATION SEQUENCING DATA; ARABIDOPSIS-THALIANA; CHROMOSOMAL INVERSIONS; DROSOPHILA-MELANOGASTER; KARYOTYPE EVOLUTION; BOECHERA-STRICTA; SPECIATION; GENOME; EXPRESSION
Description Fixed chromosomal inversions can reduce gene flow and promote speciation in two ways: by suppressing recombination and by carrying locally favoured alleles at multiple loci. However, it is unknown whether favoured mutations slowly accumulate on older inversions or if young inversions spread because they capture pre-existing adaptive quantitative trait loci (QTLs). By genetic mapping, chromosome painting and genome sequencing, we have identified a major inversion controlling ecologically important traits in Boechera stricta. The inversion arose since the last glaciation and subsequently reached local high frequency in a hybrid speciation zone. Furthermore, the inversion shows signs of positive directional selection. To test whether the inversion could have captured existing, linked QTLs, we crossed standard, collinear haplotypes from the hybrid zone and found multiple linked phenology QTLs within the inversion region. These findings provide the first direct evidence that linked, locally adapted QTLs may be captured by young inversions during incipient speciation.
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