Publication details

Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births

Authors

ŠPLÍCHAL Zbyněk ZLÁMAL Filip MÁCHAL Jan LIPKOVÁ Jolana PAVLOVÁ Tereza HODICKÁ Zuzana VENTRUBA Pavel VAŠKŮ Anna BIENERTOVÁ VAŠKŮ Julie

Year of publication 2018
Type Article in Periodical
Magazine / Source JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1080/14767058.2017.1323530
Keywords Omentin-1; adipokine; preterm birth; Val109Asp polymorphism; PPROM
Description Objective: To determine maternal omentin-1 levels and genetic variability in the omentin-1 gene in women with spontaneous term and preterm births (PTBs).Materials and methods: Maternal serum omentin-1 levels and the role of the omentin-1 Val109Asp (rs2274907) polymorphism were evaluated in 32 women with spontaneous term birth (sTB) and 30 women with spontaneous preterm birth (sPTB) including women with (n=16) and without (n=14) preterm premature rupture of membranes (PPROM).Results: Maternal omentin-1 levels were significantly lower in women with sPTBs compared to term births during the hospitalization period (p=.015). However, maternal omentin-1 levels were similar in women with sPTBs with and without PPROM (p=.990). Furthermore, the omentin-1 Val109Asp polymorphism was found to have no significant effect on omentin-1 serum levels. In addition, no significant differences in genotype distributions and allelic frequencies between sTB and sPTB were established.Conclusions: High omentin-1 levels in normal sTBs compared to PTBs without significant differences between cases with and without PPROM suggest that omentin-1 plays a potential role in the pathophysiology of PTB but not in the PPROM mechanism itself.
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