Publication details

Effect of one year antihypertensive therapy with angiotensin I converting enzyme (ACE) inhibitor on hemodynamic, hematological and biochemical parameters. Effects of I/D ACE and M235T and T174M angiotensinogen gene polymorphisms

Investor logo
Authors

VAŠKŮ Anna SOUČEK Miroslav ZNOJIL Vladimír RAMBOUSKOVÁ Lada ŘIHÁČEK Ivan CÍDL Karel STŘELCOVÁ Lenka VÁCHA Jiří

Year of publication 1999
Type Article in Periodical
Magazine / Source Scripta medica
MU Faculty or unit

Faculty of Medicine

Citation
Field Cardiovascular diseases incl. cardiosurgery
Keywords quinapril; angiotensin-converting enzyme; angiotensinogen; ambulatory blood pressure monitoring
Description The purpose of the study has been to evaluate the influence of one year angiotensin I-converting enzyme inhibitor (IACE) treatment on 24-h blood pressure (BP) and heart rate (HR) parameters, other hemodynamic (ECG, ECHO) parameters and hematological and biochemical tests in the genetic context of renin - angiotensin system gene polymorphisms. Eleven newly diagnosed essential hypertensives were treated with ACE inhibitor quinapril (Accupro, Gödecke, Berlin) for one year. All patients were genotyped for three polymorphisms - I/D of angiotensin I-converting enzyme and M235->T and T174->M of angiotensinogen genes, respectively. A decrease in the mean levels of systolic (p=0.001), mean arterial (p=0.002) and diastolic (p=0.003) blood pressures were found. No significant differences in ECG parameters nor differences in ECHO parameters became evident.However, a decrease in the red blood cell count (p=0.004) and an increase in the MCV of the RBCs (p=0.002) were observed. Differences in the blood glucose levels appeared to be associated with I/D ACE genotype (p=0.01).
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info