Publication details

The Effectiveness of Mobile-based Psychological Interventions in Reducing Psychological Distress and Preventing Stress-related Changes in Psychoneuroendocrine- immune Network in Breast Cancer Survivors- Randomized Controlled Trial - Clinical Trial Protocol Registration

Authors

SVĚTLÁK Miroslav

Year of publication 2022
MU Faculty or unit

Faculty of Medicine

Citation
Attached files
Description In this study researchers will examine an influence of three different psychological interventions in the form of mobile application on psychoneuroendocrine- immune system among breast cancer survivors. Most studies focusing on the effects of psychological interventions on healthrelated outcomes have relied on self-reports. There is also growing research interest in the effects of such interventions on directly measurable biological processes associated with chronic stress. Neuroendocrine-immune system interactions are fundamental tools through which stress affects the course of cancer. The study will examine effect of three psychological interventions on most frequently studied stress related biomarkers: cortisol, HRV (heartrate variability), CRP, relative and absolute counts of: B-lymphocytes ,Tlymphocytes, NK-cells, NK-T-like cells, monocytes; cytokine levels. Although current research suggests salutogenic changes in the immune profile of cancer patients as a result of psychological interventions, the results of individual studies are still inconsistent. To get clearer outcomes researchers decided to follow recommendations for researchers in manner that optimizes study design: to recruit very homogenous sample of cancer patients, to continue measurements in 3 and 9 months follow up, to collect data on individual´s adherence to protocol of mobile application.1,2 In addition to biomarkers, researchers will monitor changes in psychological variables.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info