Low incidence of severe acute and chronic graft-versus-host disease in a long-term retrospective study with ATG Grafalon routine use

• Authors: KOVÁCSOVÁ Flóra; FOLBER František; WEINBERGEROVÁ Barbora; ŠTĚPÁNOVÁ Radka; KABUT Tomáš; TOMÍŠKA Miroslav; KREJČÍ Marta; MAYER Jiří
• Year of publication: 2023
• Type: Article in Periodical
• Magazine / Source: Annals of hematology
• MU Faculty or unit: Faculty of Medicine
• Web: https://link.springer.com/article/10.1007/s00277-023-05479-w
• Doi: http://dx.doi.org/10.1007/s00277-023-05479-w
• Keywords: Acute and chronic GVHD; AlloHSCT; ATG Grafalon

Attached files

• Low_incidence_of_severe_acute_and_chronic_graft-versus-host_disease_in_a_long-term_retrospective_study_with_ATG_Grafalon_routine_use.pdf

• Description: Since 2006, combined graft-versus-host disease (GVHD) prophylaxis with ATG Grafalon has been our department's base of peri-transplant supportive care. This recent retrospective study included 398 patients who underwent their first allogeneic hematopoietic stem cell transplantation after receiving a defined dose of ATG Grafalon. Our observations recorded reduced incidence of severe acute and chronic GVHD without negative impact on overall survival in a nonselected group with standard and uniform GVHD prophylaxis.

Related projects

• National institute for cancer research