Publication details
5′-UTR mRNA splicing determines CD20 levels
| Authors | |
|---|---|
| Year of publication | 2023 |
| Type | Article in Periodical (without peer review) |
| MU Faculty or unit | |
| Citation | |
| Attached files | |
| Description | In this issue of Blood, Ang et al(1) show that human CD20 messenger RNA (mRNA) undergoes alternative splicing to generate distinct 5' untranslated region (5'-UTR) variants, which determine the cell-surface CD20 levels in malignant B cells and the interpatient variability in the expression of this therapeutic target. These variants can also be used as an escape mechanism from anti-CD20 therapies. |
| Related projects: |