Publication details
Comprehensive overview of adaptor protein Ruk/CIN85 roles in cancer
| Authors | |
|---|---|
| Year of publication | 2024 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Using cellular models of breast, lung, and bone cancer, the effects of Ruk/CIN85 on multiple attributes of cancer cell plasticity were investigated. It was demonstrated that overexpression of Ruk/CIN85 resulted in elevated motility in vitro and metastatic potential in vivo, while Ruk/CIN85-knockdown cells are characterized by a lack of migration and metastasis. In addition, a high expression level of Ruk/CIN85 is necessary for the acquisition of resistance to anticancer drugs. Analysis of possible molecular mechanisms revealed expression of EMT- and CSCs-related markers, ECM remodeling ability, as well as metabolic reprogramming (Warburg effect) in Ruk/CIN85-overexpressing cells. On the contrary, Ruk/CIN85 knockdown resulted in the acquisition of a more differentiated phenotype with increased adhesion and proliferation. |
| Related projects: |