Comprehensive overview of adaptor protein Ruk/CIN85 roles in cancer

• Autoři: HORAK Iryna; SKATERNA Tetiana; HUDKOVA Olha; LATYSHKO Nely; KHUDIAKOVA Olha; TOKARCHUK Kateryna; KRYSIUK Iryna; KISHKO Teriana; KNOPFOVÁ Lucia; DROBOT Liudmyla
• Rok publikování: 2024
• Druh: Konferenční abstrakty
• Fakulta / Pracoviště MU: Přírodovědecká fakulta
• Popis: Using cellular models of breast, lung, and bone cancer, the effects of Ruk/CIN85 on multiple attributes of cancer cell plasticity were investigated. It was demonstrated that overexpression of Ruk/CIN85 resulted in elevated motility in vitro and metastatic potential in vivo, while Ruk/CIN85-knockdown cells are characterized by a lack of migration and metastasis. In addition, a high expression level of Ruk/CIN85 is necessary for the acquisition of resistance to anticancer drugs. Analysis of possible molecular mechanisms revealed expression of EMT- and CSCs-related markers, ECM remodeling ability, as well as metabolic reprogramming (Warburg effect) in Ruk/CIN85-overexpressing cells. On the contrary, Ruk/CIN85 knockdown resulted in the acquisition of a more differentiated phenotype with increased adhesion and proliferation.

Související projekty

• Adaptor protein Ruk/CIN85 as a potential molecular marker in human osteosarcoma