Publication details
Kryoglobulinémie z úhlu pohledu jednotlivých medicínských odborností
| Title in English | Cryoglobulinemia from different medical perspectives |
|---|---|
| Authors | |
| Year of publication | 2024 |
| Type | Article in Periodical |
| Magazine / Source | Transfuze a hematologie dnes |
| MU Faculty or unit | |
| Citation | |
| web | https://www.prolekare.cz/casopisy/transfuze-hematologie-dnes/2024-4-14/kryoglobulinemie-z-uhlu-pohledu-jednotlivych-medicinskych-odbornosti-139494 |
| Doi | http://dx.doi.org/10.48095/cctahd2024prolekare.cz19 |
| Keywords | vasculitis; Hepatitis C; monoclonal gammopathy; cryoglobulin |
| Description | Cryoglobulinemia is defined as the persistent presence of abnormal serum immunoglobulins that precipitate at low temperatures and dissolve again upon warming. Cryoglobulins may be composed by a monoclonal Ig (type I cryoglobulinemia), by a monoclonal Ig bound to the constant domain of polyclonal Ig heavy chains (type II cryoglobulinemia), or by polyclonal Igs (type III cryoglobulinemia). Cryoglobulinemia types II and III are called mixed cryoglobulinemia. Clinical manifestations of type I cryoglobulinemia are often related to intravascular obstruction, whereas those seen in the mixed cryoglobulinemia are often due to true immune complex-mediated vasculitis. The main clinical manifestations affect the skin (purpura, necrotic ulcers), joints, peripheral nervous system, and kidneys (membranoproliferative glomerulonephritis). Patients with type I and II cryoglobulinemia should be investigated for monoclonal gammopathy and lymphoproliferative diseases. Patients with type III cryoglobulinemia should be investigated for Hepatitis C, HIV, and connective tissue disease. |