Publication details

AEON 2025: Robust Control of Partially-Specified Boolean Networks

Authors

VESELÝ Vojtěch ŠMIJÁKOVÁ Eva PASTVA Samuel BENEŠ Nikola ŠAFRÁNEK David

Year of publication 2025
Type Article in Proceedings
Conference AEON 2025: Robust Control of Partially-Specified Boolean Networks
MU Faculty or unit

Faculty of Informatics

Citation
web https://link.springer.com/book/10.1007/978-3-032-01436-8
Doi https://doi.org/10.1007/978-3-032-01436-8_4
Keywords Boolean network; Control; Reprogramming; Binary decision diagram; Automated reasoning
Attached files
Description Partially specified Boolean networks (PSBNs) provide a formal framework for the qualitative modelling of gene regulatory networks or signalling pathways in which the logic of interactions is not completely known. The tool AEON has been well-established in handling attractor analysis of PSBNs efficiently. The PSBN framework has been recently extended with algorithms supporting phenotype control allowing to stabilise the network in states exhibiting given traits. In this paper, we present a novel version of the AEON tool that supports phenotype control.

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