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AEON 2025: Robust Control of Partially-Specified Boolean Networks

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VESELÝ Vojtěch ŠMIJÁKOVÁ Eva PASTVA Samuel BENEŠ Nikola ŠAFRÁNEK David

Rok publikování 2025
Druh Článek ve sborníku
Konference AEON 2025: Robust Control of Partially-Specified Boolean Networks
Fakulta / Pracoviště MU

Fakulta informatiky

Citace
www https://link.springer.com/book/10.1007/978-3-032-01436-8
Doi https://doi.org/10.1007/978-3-032-01436-8_4
Klíčová slova Boolean network; Control; Reprogramming; Binary decision diagram; Automated reasoning
Přiložené soubory
Popis Partially specified Boolean networks (PSBNs) provide a formal framework for the qualitative modelling of gene regulatory networks or signalling pathways in which the logic of interactions is not completely known. The tool AEON has been well-established in handling attractor analysis of PSBNs efficiently. The PSBN framework has been recently extended with algorithms supporting phenotype control allowing to stabilise the network in states exhibiting given traits. In this paper, we present a novel version of the AEON tool that supports phenotype control.

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