Publication details

Cytotoxic effects of colicins E1 and E3 on v-myb-transformed monoblasts

Authors

ŠMARDA Jan FIALOVÁ Markéta ŠMARDA Jan

Year of publication 2001
Type Article in Periodical
Magazine / Source Folia Biologica
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords colicin; proliferation; cee death; v-myb; monoblasts
Description Colicins show a considerable cytostatic activity. In this communication, the cytotoxic effects of colicins E1 and E3 on v-myb-transformed chicken monoblasts BM2 are presented. We detected clear reduction of the viable cell number induced by colicin E1 and E3, occuring without apparent changes in cell cycle profiles. The level of inhibition was proportional to colicin concentration. This result documents tha colicins exert their cytotoxic effects on leukemic cells.
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