Publication details

v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts

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Authors

ŠEVČÍKOVÁ Sabina ZAHRADNÍČKOVÁ Eva SOUČEK Karel ŠMARDA Jan

Year of publication 2001
Type Article in Proceedings
Conference The 17th annual meeting on oncogenes
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords Fos
Description The fos/jun proto-oncogenes encode for proteins which are components of the AP-1 transcription complex that includes several Fos related and Jun related proteins. The AP-1 was shown to play multiple roles in functional development of hematopoietic precursor cells to mature blood cells. To gain insights into the role of fos/jun in leukemogenicity, we expressed v-fos and v-jun in the line of chicken monoblasts BM2. We found that either v-fos or v-jun-expressing BM2 cells exhibit signs of dedifferentiation. This suggests that oncogenic forms of Jun adn Fos proteins can further enforce v-Myb transformation.
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