Publication details

The Association Study of DRD2, ACE and AGT Gene Polymorphisms and Metamphetamine Dependence



Year of publication 2001
Type Article in Periodical
Magazine / Source Physiological Research
MU Faculty or unit

Faculty of Science

Field Physiology
Keywords TaqI A polymorphism; DRD2; ACE; M235T; Angiotensinogen; Metamphetamine dependence
Description We investigated for the first time the association between the metamphetamine dependence and TaqI A polymorphism of the dopamine receptor D2 gene, I/D ACE polymorphism and M235T polymorphism of the angiotensinogen gene (AGT) in 93 unrelated metamphetamine dependent subjects and 131 controls. Our results did not prove any association of the TaqI A polymorphism of the DRD2 gene, I/D polymorphism of ACE gene and M235T polymorphism of AGT gene with the metamphetamine dependence in Caucasians of Czech origin, however, a statistically significant difference in I allele frequency between male control and female control groups for the I/D ACE polymorphism (p<0.03) was found.
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