Publication details
Některé epidemiologické, patogenetické a klinické aspekty selektivního deficitu IgA
| Title in English | Some epidemiologic, pathogenetic and clinical aspects of selective IgA deficiency |
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| Authors | |
| Year of publication | 2001 |
| Type | Article in Periodical |
| Magazine / Source | Alergie |
| MU Faculty or unit | |
| Citation | |
| Field | Immunology |
| Keywords | IgA deficiency; common variable deficiency; respiratory tract infections; autoimmune diseases |
| Description | Despite its high frequency (1:408 in the Czech population), selective IgA deficiency ( IgAD) still remains an immunopathological state with many unresolved questions. Although a genetic linkage to non-aspartic acid residue on 57th position of HLA-DQ chain and frequent familiar occurrence is well documented, the real genetic basis is not known; a defect of genes of alpha heavy chains is not a cause. Very little is known about the etiopathogenesis of IgAD, probably different mechanisms may be involved in various affected persons. From the clinical point of view, IgAD is usually without clinical symptoms, but in some IgAD deficient persons proneness to frequent respiratory tract infections can be observed, namely in infancy and childhood. Also systemic and organ-specific autoimmune diseases are more frequent in IgAD persons than in general population. A clear association with allergic disorders was not documented. It is important to consider a danger of development of anti-IgA antibodies after administration of IgA containing blood derivates. These antibodies can be a cause of serious anaphylactic reactions after repeated administration of IgA-containing derivates. A treatment of IgAD is not known. |
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