Publication details

Nucleolus and Apoptosis

Authors

HORKÝ Marcel KOTALA Vladimír ANTON Milan WESIERSKA-GADEK Jozefa

Year of publication 2002
Type Article in Periodical
Magazine / Source Annals of the New York Academy of Sciences
MU Faculty or unit

Faculty of Medicine

Citation
Field Genetics and molecular biology
Keywords nucleolus; proliferation; apoptosis
Description The nucleolus represents a highly dynamic nuclear compartment of the interphase nucleus. It plays a key role in ribosome biogenesis. The number of nucleoli, their size, and their activity increase in exponentially growing cells; therefore these parameters reflect the proliferating activity of the cells. Nucleolar changes and pleomorphism associated with overt proliferation of tumor cells have also been documented by immunohistochemical and ultrastructural studies. Contrary to cell proliferation, cytostatics-induced changes of nucleolar phenotype in malignant cells point to a potential role of nucleolar components in the execution of active cell death. It can be concluded that the plurifunctionality of nucleoli regarding cell proliferation and apoptosis could open new vistas toward understanding dysregulation in malignant cells.
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