Publication details
Kdy je polyfarmakoterapie léčbou první nebo druhé volby - I. část
| Title in English | polypharmacotherapy - when is it Treatment of the First or Second Choice? part I. |
|---|---|
| Authors | |
| Year of publication | 2003 |
| Type | Article in Periodical |
| Magazine / Source | Česká a slovenská psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Psychiatry, sexuology |
| Keywords | polypharmacotherapy; schizoaffective disorder; bipolar disorder; combinations with mood stabilizers; atypical antipsychotics |
| Description | Data about treatment of schizoaffective and bipolar disorders are summarised. In both disorders the frequent first choice is the combination of mood stabilizers and antipsychotics, respective antidepressants. In th 70's lithium was very popular, in the 80's anticonvulsants appeared and in the 90's atypical antipsychotics started to bi in the focus of attention. It is not clear whether atypical antipsychotics are mood stabilizers, because there is a lack of adequate studies. The authors data about the treatment of schizoffective disorders are presented. The authors, using retrospective chart analysis, found taht in this indication antipsychotics were preferred. On admission mood stabilizers were used in 20/64 (31%), only in 3/20 (15%) as monotherapy and in combination, in 46/64 (72%) antipsychotics were used. Atypical antipsychotics were preferre(33/46, 72%)to conventional antipsychotics (21/46, 46%). This ratio persisted on discharge. On discharge a higher number of patients were treated with antipsychotics (72% vs 91%), combinations of antipsychotics with mood stabilizers (26% vs 40%) and combinations of antipsychotics (13% vs 22%). The most widely used atypical antipsychotic on admission was risperidone (in 39%), on discharge olanzapine (in 35% of the total number of patients treated with atypical antipsychotics). |
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