Publication details
Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments
| Authors | |
|---|---|
| Year of publication | 2003 |
| Type | Article in Proceedings |
| Conference | Proceedings of symposium: Chronobiological analysis in pathophysiology of cardiovascular system |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | rate dependence; action potential; action potential voltage clamp; rat; ajmaline |
| Description | Components of the total ionic current responsible for rate-dependent changes of action potential (AP) configuration were analyzed by the AP clamp method in isolated rat ventricular myocytes. The results demonstrate that besides Ca2+-mediated currents, cumulative inactivation of the transient outward current Ito significantly participates on the rate-dependent variability of AP configuration. Under the effect of antiarrhythmic drug ajmaline (30mikromol/l), the fast sodium current INa causes marked changes in the repolarization phase of AP, very likely as a consequence of its use-dependent block. |
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