Physiological consequences of ionic concentration changes in cardiac cell tubular System

• Authors: PÁSEK Michal; CHRISTÉ Georges; ŠIMURDA Jiří
• Year of publication: 2004
• Type: Article in Proceedings
• Conference: Biomechanics of Man
• MU Faculty or unit: Faculty of Medicine
• Field: Biophysics
• Keywords: cardiac cell; tubular system; quantitative modelling
• Description: Experimental data related to the tubular system of guinea pig and rat ventricular cell were summarized and incorporated into quantitative models of cellular activity. The results of simulations suggest that activity-dependent depletion of Ca2+ within the t-tubule lumen lowers the intracellular Ca load, intracellular Ca2+ transients and hence the inotropic status of ventricular myocytes.

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