Publication details

ECG segment variability during voltage-sensitive dye application in animal heart

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Year of publication 2005
Type Article in Periodical
Magazine / Source Scripta medica
MU Faculty or unit

Faculty of Medicine

Field Physiology
Keywords voltage-sensitive dye di-4-ANEPPS; ECG signal; wavelet analysis; dynamic time warping
Description The optical mapping of action potentials from heart surface has been used extensively as a new possibility of non-invasive recording methods. It employs application of voltage-sensitive dyes(VSDs). Previously, VSDs have been successfully used in myocardial ischemia studies. Our previous Langendorff-perfused heart experiments have suggested shape changes in ECG signals in time and time-frequency domain caused by application of VSD di-4-ANEPPS during optical mapping. These changes went through detailed analysis to reveal impact on particular fractions of a heart cycle. The heart cycle was divided into three parts, corresponding to P-Q segments, QRS complexes, and ST-T segments. Dynamic time warping (DTW) is applied to all marked segments in each experimental period (control, loading, and washout phase). Variability of ECG parts is measured by means of an optimal path resulting from DTW based on minimum distance between the control signal segments (before the application of VSD) and segments recorded in the next two experimental steps.
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