Publication details

Molecular biology of ADHD: an association study of DAT1, DRD2, DRD4, COMT and MAOB gene polymorphisms with hyperactive disorder in children



Year of publication 2006
Type Article in Proceedings
Conference 3rd International Biology Students Conference 2006, April 6.-9. 2006
MU Faculty or unit

Faculty of Science

Field Psychiatry, sexuology
Keywords ADHD; DAT1; DRD2; DRD4; COMT; MAOB; gene; polymorphism
Description Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder with significant genetic contribution, one of the most commonly diagnosed neurobehavioral disorders in a childhood. The hyperactivity is the disorder of behavior affecting 3-6% of school age children wordwide; the main symptoms are inattention, impulsivity and distractibility. In the past few years, interest in the molecular psychiatry genetics of ADHD has grown enormously, with many groups searching for susceptibility genes. Dopamine genes have been the initial candidates based on the site of the action of the psychostimulant drugs. We have investigated whether there is an association of dopamine system candidate genes DAT1, DRD2, DRD4, COMT and MAOB with ADHD. The aim of our case-control study was to determine whether the ADHD boys (118) have different genotype and alelic frequencies of examined genes compared to controls (153). No significant differences were found between groups of boys in polymorphism genes DRD4, COMT and MAOB (p > 0.05). The statistical analysis using Fisher exact test did not confirme the association of the previously possitive investigated 10-repeat allele or 10/10 genotype of DAT1 gene (p = 0.531). However, we found the association of long 10/11 genotype of DAT1 gene (p = 0.0063). The difference in the frequency of 10/11 genotype may signify that rare 11 allele may increase higher risk of ADHD. For DRD2, ADHD probands were more likely than controls to have the A1 allele and genotype A1A1 (p = 0.0013). Our results showed that ADHD in Czech children population is associated with TaqI A polymorphism of DRD2 gene, the presence of DRD2 A1 allele increase the risk of ADHD.
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