Publication details

ELEVACE OXIDATIVNÍHO STRESU U PACIENTŮ SE SPINOCELULÁRNÍM KARCINOMEM HLAVY A KRKU

Title in English Elevation of oxidative stress in head and neck squamous cell carcinoma
Authors

SALZMAN Richard KOSTŘICA Rom PÁCAL Lukáš KAŇKOVÁ Kateřina TOMANDL Josef HORÁKOVÁ Zuzana ROTTENBERG Jan ZICHOVÁ Iva

Year of publication 2006
Type Article in Proceedings
Conference Sbroník abstrakt, XXX. Brněnské onkologické dny
MU Faculty or unit

Faculty of Medicine

Citation
Field ORL, ophthalmology, stomatology
Keywords oxidative stress; HNSCC; reactive oxygen species; malondialdehyde; GPx; SOD
Description Much focus is paid on a role of oxidative stress in cancerogenesis. The aim of aour study was to evaluate parameters of oxidative stress in a group of patients with HNSCC and compare these results with a control group of healthy patients Our study revealed higher amount of TNF, MDA in oncological patients. Consistently, superoxid dismutase activity in red blood cells was decreased in patients with malignancies of head and neck. In conclusion, increased levels of MDA and TNF without compensatory elevation of amount or activity of antioxidative enzymes in patients with HNSCC entitles us to presume that oxidative stress plays an important role in cancerogenesis of HNSCC. Subapriya came to similiar results.The project is supported by grant 10/IINR/7996-3 from IGA of The Czech Ministry of Health.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info