Interference of N-heterocyclic PAHs with signaling of retinoids

• Authors: BENÍŠEK Martin; PACHERNÍK Jiří; BLÁHA Luděk; HILSCHEROVÁ Klára
• Year of publication: 2007
• Type: Conference abstract
• MU Faculty or unit: Faculty of Science
• Description: N-heterocyclic analogs of PAHs (N-PAHs) are as well as homocyclic PAHs important and widespread environmental contaminants. Many of them are carcinogens, mutagens and teratogens. Some results indicate that N-PAHs have higher toxic and genotoxic potencies and bioavailability than PAHs. In this study the interference of N-PAHs with retinoid signaling system was tested. After 24 h exposure most of three, four and five ring PAHs and N-PAHs increased RA activity. Obtained data were statistically analyzed and quantitative-structure activity relationship study was performed. This study was supported by GACR 525/05/P160.

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