Publication details

Srovnání vybraných markerů dendritických buněk u zdravých dárců a pacientů s monoklonální gamapatií nejasného významu či mnohočetným myelomem

Title in English Comparison of DCs antigens in healthy volunteers and monoclonal gammopathy and/or multiple myeloma patients

KOVÁŘOVÁ Lucie MICHÁLEK Jaroslav KÝR Michal PENKA Miroslav HÁJEK Roman

Year of publication 2008
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Field Oncology and hematology
Keywords dendritic cells; monoclonal gammopathy of undetermined significancy; multiple myeloma; flowcytometry
Description Dendritic cells are higly specialized antigen-presenting cells, which can be used for immunotheraphy trials. Functionally normal DCs play a critical role in the activation and potentiation of tumor antigen-specific responses. Under serum free conditions there was no difference in healthy volunteers, MGUS and MM patients, but CD40L stimulation did not lead to the full maturation of DCs. Patients autologous serum had a negative influence on DCs, but it was depending not only on IL-6 level.
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