Publication details
Význam sledování exprese nádorových testikulárních antigenů u mnohočetného myelomu a monoklonálních gamapatií
| Title in English | Impact of cancer/testis antigens /(CTA) expression in multiple myeloma (MM) and monoclonal gammapathy (MGUS) |
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| Authors | |
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | Klinická onkologie Supplement 2008 |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | multiple myeloma; monoclonal gammapathy; cancer/testis antigen |
| Description | The human MAGE gene family which is a group of "cancer/testis antigens" (CTA) encodes products that can be recognized by autologous cytotoxic T cells. CT antigens are expressed in several malignant tumors, but not in normal tissues except for testis and placenta. CT antigens are frequently expressed in MM and represents promising candidates for cancer- specific immunotherapy in multiple myeloma. An obvious correlation between the expression of these genes and the stage of the disease has been observed. We examined the expression of MAGE-A1 and MAGE-A3 in bone marrow in a group of patiens with monoclonal gammapathy and in patients with early and advanced stage of the multiple myeloma. |
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