Centrosome amplification as a possible marker of mitotic disruptions and cellular carcinogenesis in multiple myeloma

• Authors: DEMENTYEVA Elena Vladimirovna; NĚMEC Pavel; KRYUKOV Fedor; MUTHU RAJA Karthick Raja; SMETANA Jan; ZAORALOVÁ Romana; GREŠLIKOVÁ Henrieta; KUPSKÁ Renata; KUGLÍK Petr; HÁJEK Roman
• Year of publication: 2010
• Type: Article in Periodical
• Magazine / Source: Leukemia Research
• MU Faculty or unit: Faculty of Medicine
• Field: Oncology and hematology
• Keywords: Multiple myeloma; B-cells; Plasma cells; Centrosome amplification
• Description: Centrosome amplification (CA) as a potential marker of mitotic disruptions in multiple myeloma (MM) was investigated in two populations of B-cell lineage: B-cells and plasma cells (PCs). There was no significant correlation between CA-positive MM cases (based on PC samples evaluation) and the occurrence of cytogenetic abnormalities in PCs, including del(13)(q14), del(17)(p13), gain(1)(q21) and hyperdiploidy.

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