Publication details
Autosomálně dominantní polycystóza ledvin u plodu se zdánlivě negativní rodinnou anamnézou - kazuistika
| Title in English | Autosomal Dominant Polycystic Kidney Disease in The Fetus with Seemingly Negative Family History |
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| Authors | |
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Česko-Slovenská patologie a soudní lékařství |
| MU Faculty or unit | |
| Citation | |
| Field | Other medical specializations |
| Keywords | polycystic kidney disease; ADPKD; fetal autopsy; prenatal diagnosis |
| Description | An unusual case of fetal polycystic kidney disease is reported. Oligohydramnios and enlarged hyperechogenic kidneys were found at 21 weeks. The pregnancy was terminated and fetal autopsy performed. The histopathologic pattern of fetal kidneys raised suspicion of ADPKD. The mothers diagnosis was established only after the abortion of the affected fetus. She had no symptoms of the disease. Multigenerational involvement was revealed on the mothers side. Mechanisms leading to prenatal ADPKD and prognosis of the pediatric patients are discussed. |