Publication details

Zvýšení toxicity perzistentních organických polutantů v přítomnosti huminových látek

Title in English Enhancement of toxicity of various persistent organic pollutants after interaction with dissolved humic substances
Authors

BITTNER Michal NOVÁK Jiří GIESY John P. HILSCHEROVÁ Klára

Year of publication 2010
Type Article in Periodical
Magazine / Source Bulletin VÚRH Vodňany
MU Faculty or unit

Faculty of Science

Citation
Field Water pollution and control
Keywords humic substances; dioxin-like toxicity; aryl hydrocarbon receptor
Description Humic substances (HS) are ubiquitous natural products of natural organic matter decomposition. We describe in vitro effects of binary mixtures of various HS samples with model compounds from different classes of environmental pollutants in H4IIE-luc cell line. Six out of 12 HS samples activated AhR even at environmentally relevant concentrations (17 mg.l-1), but did not induce full AhR-activation even at excessive concentration. In simultaneous exposure of H4IIEluc cells to HS (17 mg.l-1) and each of the model compounds, TCDD (1.2 pM), PCB126 (0.01nM), benzo[a]pyrene (40nM), benzo[a]anthracene (240nM), dibenz[a,h]anthracene (1nM) and fluoranthene (40,000nM), either significant additive or facilitative effects were observed when compared to the activities of the single model pollutants. No negative interactions, due to possible sorption of model compounds to HS, were observed.
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