Publication details

Visualization of Numerical Centrosomal Abnormalities by Immunofluorescent Staining

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KRYUKOV Fedor DEMENTYEVA Elena Vladimirovna KUGLÍK Petr HÁJEK Roman

Year of publication 2011
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Field Oncology and hematology
Keywords multiple myeloma; B cells; centrosome amplification; plasma cells
Description The presence of multiple centrosomes in tumor cells is associated with the formation of multipolar mitotic spindles and results in aneuploidy of both daughter cells. Centrosome amplification is a feature of all cancer cells. We have previously described centrosome amplification in abnormal B cells. Further studies of centrosome amplification in different stages of B lineage development could provide important information about multiple myeloma pathogenesis.
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