Publication details

Association between alpha-2-adrenergic receptor polymorphism and schizophrenia



Year of publication 2012
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Science

Description The important role of adrenergic system in psychiatric disorder such as depression and schizophrenia has been proved. Alpha-2-adrenergic receptor plays a key role in regulation of neurotransmitter releasing from sympathetic nerves and adrenergic neurons and have been implicated in mediating antipsychotic response. Further the role of alpha-2-adrenergic receptor in pathophysiology of schizophrenia is supported by the fact that many of the successful antipsychotics demonstrate affinity to these receptors. In this study we investigated -1291 C/G polymorphism in the promoter region of alpha-2-adrenergic receptor candidate gene. We focused to regulatory region of candidate gene because schizophrenia might be a chronic disease and there is a suggestion that regulatory regions of genes may be particularly relevant to chronic diseases. The patients (n= 170) were diagnosed by clinicians according to DSM-IV criteria and control subjects (n = 190) comprised individuals with no prior history of mental or neurological illness. All subjects in the present study were Czech origin. DNA was isolated from blood or bucal swabs samples and SNP -1291 C/G in alpha-2-adrenergic receptor gene was analysed by SNaPshot method on genetic analyzer 3130. Association study on -1291 C/G polymorphism was performed in relation to schizophrenia. The genotype distribution was found to be without deviation from Hardy-Weinberg equilibrium. A statistically significant difference was found when the allelic frequencies between the two groups were compared (p<0.003), with OR=1.73 for allele frequencies relative to schizophrenia. Our results presented a clearly positive correlation
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