Využití in vitro biotestů pro hodnocení kontaminace vodního prostředí AhR-aktivními látkami.

• Title in English: USE OF IN VITRO BIOASSAYS TO EVALUATE CONTAMINATION OF AQUATIC ENVIRONMENT WITH AhR-ACTIVE COMPOUNDS
• Authors: MACÍKOVÁ Petra; GIESY J.; HILSCHEROVÁ Klára
• Year of publication: 2011
• Type: Article in Periodical
• Magazine / Source: Bulletin VÚRH Vodňany
• MU Faculty or unit: Faculty of Science
• Field: Environment influence on health
• Keywords: AhR-dependent toxicity; river ecosystem; passive sampling; in vitro assays
• Description: The aquatic environment is contaminated with many types of chemical compounds that can be dissolved in water or bound to solid particles and in sediments. In complex mixtures is very difficult to estimate their toxic potential. Many types of hydrophobic persistent pollutants are able to activate arylhydrocarbon receptor (AhR) that might have negative consequences for organisms’ health. Suitable tools to assess AhR-active (dioxin-like) compounds in aquatic samples are in vitro bioassays in combination with chemical analysis.

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