Publication details

Význam mikroprostředí kostní dřeně v patogenezi mnohočetného myelomu

Title in English Implication of Bone Marrow Microenvironment in Pathogenesis of Multiple Myeloma
Authors

FIŠEROVÁ Barbora KUBICZKOVÁ Lenka ŠEVČÍKOVÁ Sabina HÁJEK Roman

Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords Multiple myeloma; bone marrow microenvironment; pathogenesis; treatment
Description Multiple myeloma is a hematooncological disease characterized by malignant proliferation of plasma cells. These cells accumulate in the bone marrow where they suppress physiological hematopoiesis; at the same time, these cells interact with a wide variety of cytokines, growth factors and adhesion molecules. It is obvious that the bone marrow microenvironment plays an important role in disease pathogenesis as well as treatment resistance.
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