Project information

Epigenetic control of gene expression in malignant diseases

Project Identification
NC6987
Project Period
1/2002 - 12/2004
Investor / Pogramme / Project type
Ministry of Health of the CR
MU Faculty or unit
Faculty of Informatics
Keywords
DNA-microarrays;cancer;chromosome structure;epigenetic regulation;cell differentiation
Cooperating Organization
Institute of Biophysics
University Hospital Brno-Bohunice
Masaryk Memorial Cancer Institute Brno

Using DNA-microarray technology, the transcirptome maps will be determined for several normal and tumor cell populations in different stages of progression. Comparison ot maps should allow us to find out combinations of genes related to cancerogenesis. The structure of chromosomes will be inbestigated in interphase 3D-fixed nuclei by means of FISH and high-resolution cytometry. Changes of the structure re latively to the normal tissue xill be compared with changes of gene expression. Conclusion will be made on the relationship between the structure of chromosomes and expression of genes during cancerogenesis. It may give us new and relatively cheap method for the detection of oncogenic transformation in the specific tissue. The project will bring DNA-microarrays to the second laboratory in the Czech Republic, which will be important for the regional development of progressive tehnologies.

Publications

Total number of publications: 18


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