Project information
Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
- Project Identification
- MSM0021622430
- Project Period
- 1/2007 - 12/2013
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Science
- Other MU Faculty/Unit
- Faculty of Informatics
- Other MU Faculty/Unit
- Central European Institute of Technology
- Keywords
- embryonic stem cells
The goal of this project will be a) to profit from availability of unique cellular resources - mouse and human embryonic stem cells and normal and malignant hematopoietic stem/progenitor cells, b) to effectively employ a wide variety of current and complementary methodologies available to the consortium, and c) to exploit a proven/certified expertise in working with various living systems that span from in vitro cultured cells, through animal models to oncohematological patients. All this together will represent a powerful experimental platform aimed at addressing a nature of molecules and molecular mechanisms underlaying phenomena that are common to both normal and cancer stem cells, mainly their ability to self-renew and to enter differentiation pathways. Integral part of this general goal is to implement multifaceted analytical approach that will cover studies of gene expression at both mRNA and protein levels, evaluating function of extra and intracellular signaling pathways, and analyzing biological properties of cells in vitro and in vivo. Expected outcome will be not only understanding but also a definition of molecules and/or molecular pathways to be tested as therapeutic targets, and cellular models that will make such testing feasible.
Publications
Total number of publications: 361
2013
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Differential effects of insulin and dexamethasone on pulmonary surfactant-associated genes and proteins in A549 and H441 cells and lung tissue
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, year: 2013, volume: 32, edition: 1, DOI
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Differentiation of human embryonic stem cells towards distal lung epithelial cells
Year: 2013, type: Appeared in Conference without Proceedings
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Differentiation of neural crest cells from human embryonic stem cells and their odontogenic induction
Year: 2013, type: Appeared in Conference without Proceedings
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Distinct frequency and profiles of TP53 gene mutations in CLL subgroups with distinct antigen receptors: Evidence for antigen-driven selection of genomci aberrations.
Year: 2013, type: Conference abstract
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Dráha Wnt/PCP ovlivňuje kromě patogeneze chronické lymfocytární leukemie i vývoj B-lymfocytů
Year: 2013, type: Conference abstract
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Expression of FGF19 in Human Embryonic Stem Cells
STEM CELLS, year: 2013, volume: 31, edition: 11, DOI
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Fludarabine with cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients with poor-risk chronic lymphocytic leukemia
Annals of hematology, year: 2013, volume: 92, edition: 2, DOI
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Formation of Secretory Senescent Cells in Prostate Tumors: The Role of Androgen Receptor Activity and Cell Cycle Regulation
Tumor Dormancy, Quiescence and Senescence, year: 2013, number of pages: 14 s.
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Higher anti-tumour efficacy of platinum(IV) complex LA-12 is associated with its ability to bypass M-phase entry block induced in oxaliplatin-treated human colon cancer cells
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Human Embryonic and Induced Pluripotent Stem Cells Express TRAIL Receptors and Can Be Sensitized to TRAIL-Induced Apoptosis
Stem Cells and Development, year: 2013, volume: 22, edition: 22, DOI