Project information

Adsorption of bases, nucleosides, nucleotides and polynucleotides on electrods

Project Identification
IAA4004702
Project Period
1/1997 - 12/1999
Investor / Pogramme / Project type
Academy of Sciences of the Czech Republic
MU Faculty or unit
Faculty of Science
Cooperating Organization
Institute of Biophysics

The adsorption of nucleic acid bases, nucleosides, nucleotides and polynucleotides adsorbed at the surfaces of mercury, and graphite will be studied by the electrochemical impedance spectroscopy. The interactions between adsorbed bases can result in their two-dimensional (2-D) condensation and formation of a compact layer. The effect of solvent on the kinetic of 2-D condensation of nucleic acid bases and compounds used to facilitate anchoring of DNA in the scanning tunneling microscopy (SFM) will be studied. The interaction energies of nucleic acid bases in the comact layers will be calculated and the effect of methyl- and halofen substituents of bases on this energy and on the kinetic of adsorptopn and condensation will be determined. The experimental results will be compared with the quantum chemical calculations.

Publications

Total number of publications: 10


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