Publication details

Molecular heterogeneity and centrosome-associated genes in multiple myeloma

Authors

KRYUKOV Fedor NĚMEC Pavel DEMENTYEVA Elena KUBICZKOVÁ Lenka IHNATOVÁ Ivana BUDINSKÁ Eva JARKOVSKÝ Jiří ŠEVČÍKOVÁ Sabina KUGLÍK Petr HÁJEK Roman

Year of publication 2013
Type Article in Periodical
Magazine / Source Leukemia & Lymphoma
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.3109/10428194.2013.764416
Field Oncology and hematology
Keywords Multiple myeloma; centrosome abnormalities; gene expression profile
Attached files
Description In multiple myeloma (MM), biologic complexity originates from complex oncogenic processes involving somatic acquisition of myriad mutations coupled with genetic variability within the host. This pathogenically determined molecular heterogeneity predetermines clinical intricacy. In this study, we performed gene expression profi ling (GEP) focusing on centrosome-related genes to determine the molecular heterogeneity for centrosomeassociated genes in patients with MM. We identifi ed the gene pattern with an impact on myeloma pathogenesis. According to expression tendency, three subgroups of patients were established. The revealed molecular signature is related to overall survival as well as to clinical parameters and the International Staging System. Associations with integral clinical parameters allow us to proclaim the impact of the revealed functional gene set in MM genesis. We believe that future investigation of this molecular heterogeneity will help to refi ne the broad prognoses off ered by present-day established systems and even sub-stratify them.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info