Informace o publikaci

Molecular heterogeneity and centrosome-associated genes in multiple myeloma

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KRYUKOV Fedor NĚMEC Pavel DEMENTYEVA Elena KUBICZKOVÁ Lenka IHNATOVÁ Ivana BUDINSKÁ Eva JARKOVSKÝ Jiří ŠEVČÍKOVÁ Sabina KUGLÍK Petr HÁJEK Roman

Rok publikování 2013
Druh Článek v odborném periodiku
Časopis / Zdroj Leukemia & Lymphoma
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.3109/10428194.2013.764416
Obor Onkologie a hematologie
Klíčová slova Multiple myeloma; centrosome abnormalities; gene expression profile
Přiložené soubory
Popis In multiple myeloma (MM), biologic complexity originates from complex oncogenic processes involving somatic acquisition of myriad mutations coupled with genetic variability within the host. This pathogenically determined molecular heterogeneity predetermines clinical intricacy. In this study, we performed gene expression profi ling (GEP) focusing on centrosome-related genes to determine the molecular heterogeneity for centrosomeassociated genes in patients with MM. We identifi ed the gene pattern with an impact on myeloma pathogenesis. According to expression tendency, three subgroups of patients were established. The revealed molecular signature is related to overall survival as well as to clinical parameters and the International Staging System. Associations with integral clinical parameters allow us to proclaim the impact of the revealed functional gene set in MM genesis. We believe that future investigation of this molecular heterogeneity will help to refi ne the broad prognoses off ered by present-day established systems and even sub-stratify them.
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