Publication details

Near-Infrared Fluorescent 9-Phenylethynylpyronin Analogues for Bioimaging

Authors

PASTIERIK Tomáš ŠEBEJ Peter MEDALOVÁ Jiřina ŠTACKO Peter KLÁN Petr

Year of publication 2014
Type Article in Periodical
Magazine / Source The Journal of Organic Chemistry
MU Faculty or unit

Faculty of Science

Citation
Web http://pubs.acs.org/doi/abs/10.1021/jo500140y
Doi http://dx.doi.org/10.1021/jo500140y
Field Organic chemistry
Keywords Rhodamine analogue; Bioimaging; Near infrared fluorescence
Description The syntheses and biological applications of two novel fluorescent 9-phenylethynylpyronin analogues containing either carbon or silicon at the position 10 are reported. Both fluorescent probes exhibited a relatively strong fluorescence in methanol and phosphate buffer saline in the near-infrared region (705–738 nm) upon irradiation of either of their absorption maxima in the blue and red regions. The compounds showed high selectivity toward mitochondria in myeloma cells in vivo and allowed their visualization in a favored tissue-transparent window, which makes them promising NIR fluorescent tags for applications in bioimaging.
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