Publication details

Alkaline phosphatase in stem cells

Authors

ŠTEFKOVÁ Kateřina PROCHÁZKOVÁ Jiřina PACHERNÍK Jiří

Year of publication 2015
Type Article in Periodical
Magazine / Source Stem Cells International
MU Faculty or unit

Faculty of Science

Citation
Web http://dx.doi.org/10.1155/2015/628368
Doi http://dx.doi.org/10.1155/2015/628368
Field Genetics and molecular biology
Keywords alkaline phosphatase; stem cell; MSC; ESC
Description Alkaline phosphatase is an enzyme commonly expressed in almost all living organisms. In humans and other mammals, determinations of the expression and activity of alkaline phosphatase have frequently been used for cell determination in developmental studies and/or within clinical trials. Alkaline phosphatase also seems to be one of the key markers in the identification of pluripotent embryonic stem as well as related cells. However, alkaline phosphatases exist in some isoenzymes and isoforms, which have tissue specific expressions and functions. Here, the role of alkaline phosphatase as a stem cell marker is discussed in detail. First, we briefly summarize contemporary knowledge of mammalian alkaline phosphatases in general. Second, we focus on the known facts of its role in and potential significance for the identification of stem cells.
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